TCF7L2Polymorphisms and Progression to Diabetes in the Diabetes Prevention Program
نویسندگان
چکیده
منابع مشابه
Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program.
OBJECTIVE To determine whether baseline adiponectin levels or intervention-associated change in adiponectin levels were independently associated with progression to diabetes in the Diabetes Prevention Program (DPP). RESEARCH DESIGN AND METHODS Cox proportional hazards analysis was used to evaluate the contribution of adiponectin and treatment-related change in adiponectin to risk of progressi...
متن کاملTCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
BACKGROUND Common polymorphisms of the transcription factor 7-like 2 gene (TCF7L2) have recently been associated with type 2 diabetes. We examined whether the two most strongly associated variants (rs12255372 and rs7903146) predict the progression to diabetes in persons with impaired glucose tolerance who were enrolled in the Diabetes Prevention Program, in which lifestyle intervention or treat...
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Introduction: Diabetes Prevention and Control has become among the nation's health system priorities in recent decade. Meanwhile, educational programs for executives have been designed and implemented. Tha aim of this study was to describe the situation of training of general practitioners who care diabetiv patients under National Diabetes Prevention and Control Program. Methods: This study is...
متن کاملEvaluation of a mathematical model of diabetes progression against observations in the Diabetes Prevention Program.
The seminal publication of the Diabetes Prevention Program (DPP) results in 2002 has provided insight into the impact of major therapies on the development of diabetes over a time span of a few years. In the present work, the publicly available DPP data set is used to calibrate and evaluate a recently developed mechanistic mathematical model for the long-term development of diabetes to assess t...
متن کاملThe cost-effectiveness of diabetes prevention: results from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study
BACKGROUND The Diabetes Prevention Program (DPP) was a randomized, controlled clinical trial. It demonstrated that among high-risk individuals with impaired glucose tolerance, diabetes incidence was reduced by 58 % with lifestyle intervention and 31 % with metformin compared to placebo. During the Diabetes Prevention Program Outcomes Study (DPPOS), all DPP participants were unmasked to their tr...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2006
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa062418